Bibliography

Nathan Pritikin Research Foundation Bibliography - Published Research Articles

Tragically, millions of Americans, including many doctors, still believe that the only way to treat heart disease and other illnesses is with surgeries and drugs. There is very little emphasis on prevention or diet.

That’s why, for the past 30 years, we've devoted funds solely for our nonprofit Nathan Pritikin Research Foundation (NPRF). The purpose of NPRF is to publish research that persistently and persuasively proves to doctors, health institutions, and the media that the best way to halt most of modern society’s diseases is the simplest way – with good nutrition and exercise. We believe that the right message, if delivered well, and if bolstered by research, will save millions of lives.

Lead by scientists at UCLA, NPRF has published more than 100 studies in peer reviewed journals like the New England Journal of Medicine documenting the extraordinary benefits of the Pritikin Program. It is research demonstrates that dietary changes and regular exercise can prevent, treat, and reverse – rapidly and economically – America’s epidemic diseases, including heart disease, diabetes, hypertension, obesity, and many cancers. It is research that saves lives.

2009 Research Studies

Analyzing serum-stimulated prostate cancer cell lines after low-fat, high-fiber diet and exercise intervention.
Soliman, S., W.J. Aronson, R.J. Barnard. Evid Based Complement Alternat Med 2009; doi: 10.1093/ecam/nep031

Last Updated ( Thursday, 30 April 2009 09:21 )

2008 Research Studies

The Pritikin Program was found to reduce prostate cancer cell growth by as much as 45%, which should drastically reduce the risk for clinical cancer. Reductions in serum insulin, free testosterone, estradiol, and IGF-1 along with a rise in SHBG and IGFBP-1 appear important. The decrease in IGF-1 appears to be the most significant change because IGF-1 normally prevents cells from going into apoptosis (cell death).
Barnard, R.J. Cancer of the Prostate, Benign Prostatic Hypertrophy, Diet and Exercise Intervention. www.Vitasearch.com. May, 2008

Studying the effect of dietary fat on prostate cancer development, UCLA researchers found that animals on a low-fat diet (12% calories from fat) were significantly less likely to develop invasive prostate cancer compared to animals on a high-fat diet (42% calories from fat).
Kobayashi, N., R.J. Barnard, J. Said, J. Hong-Gonzales, D.M. Corman, M. Ku, N.B. Doan, D. Elashoff, P. Cohen, W.J. Aronson. Effect of low fat diet on development of prostate cancer and the Akt pathway. Cancer Res. 68:3066-3073,2008

The Pritikin Program was found to significantly reduce the growth of prostate epithelial cells, which could reduce risk of Benign Prostate Hyperplasis, common among men 50 and older in industrialized societies.
Barnard, R.J., N. Kobayashi, W.J. Aronson. Effect of diet and exercise intervention on the growth of prostate epithelial cells. Prostate Cancer Prostatic Dis. 11:362-366,2008

For significant weight loss and long-term maintenance, UCLA researchers assert importance of regular exercise and a healthy low-fat diet (high in fiber-rich whole foods).
Roberts, C.K., R.J. Barnard, and D.M. Croymans. Correspondence to the Editor: Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet. New England Journal of Medicine 359 (20): 2169, 2008.

2007 Research Studies

The Pritikin Program Was Shown To:

Reduce Several Risk Factors For Heart Disease In Children
Roberts, C.K., A.K. Chen, R.J. Barnard. Effect of a short-term diet and exercise intervention in youth on atherosclerotic risk factors. Atherosclerosis 191:98-106,2007

Prevention of Prostate Cancer: Soy Supplements Did Not Decrease IGF-I Levels
Dewell, A., G. Weidner, M.D. Sumner, R.J. Barnard, R.O. Marlin, J.J. Daubenmier, P.R. Carroll, D. Ornish. Evaluation of dietary protein and soy isoflavones in relation to serum IGF-I and IGF binding proteins in the Prostate Cancer Lifestyle Trial. Nutrition and Cancer 58:35-42,2007

Reduce Risk of Prostate Cancer
Barnard, R.J. P.S. Leung, W.J. Aronson, P. Cohen, L.A. Golding. A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer. The European Journal of Cancer Prevention 16:415-421, 2007

Alleviate the Metabolic Syndrome, Which May Help Prevent Prostate Cancer
Barnard, R.J. Prostate cancer prevention by nutritional means to alleviate metabolic syndrome. The American Journal of Clinical Nutrition 86(suppl):889S-893S,2007

2006 Research Studies

The Pritikin Program Was Shown To:

Alleviate the Metabolic Syndrome
Roberts, C.K., D. Won, S. Pruthi, S. Kurtovic, R.K. Sindhu, N.D. Vaziri, R.J. Barnard. Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9 and monocyte chemotactic activity in men with metabolic syndrome factors. J Appl Physiol 100:1657-1665,2006; and

Physical Activity and Dietary Intervention for Chronic Diseases: A Quick Fix After All
Booth, F.W., M.V. Chakravarthy. J Appl Physiol (Invited Editorial) 100:143901440,2006

Alleviate the Metabolic Syndrome In Children
Chen, A., C.K. Roberts and R.J. Barnard. Effect of a short-term diet and exercise intervention on metabolic and anthropometric parameters in overweight children and adolescents. Metabolism 55:871-878,2006

Reduce Oxidative Stress, Therefore Reducing the Risk of Heart Attacks and Strokes
Roberts, C.K., R.J. Barnard, R.K. Sindhu, M. Jurczak, A. Ehdaie, N.D. Vaziri. Oxidative stress and dysregulation of NAD(P)H oxidase and anitoxidant enzymes in diet-induced metabolic syndrome. Metabolism 55:928-934,2006

Reduce Oxidative Stress In Diabetic Men, Therefore Reducing the Risk of Heart Attacks and Strokes
Roberts, C.K., D. Won, S. Pruthi, R.J. Barnard Effect of diet and exercise intervention on oxidative stress, inflammation and monocyte adhesion in diabetic men. Diabetes Res. 73:249-259,2006

Retard the Growth of Breast Cancer Cells
Barnard, R.J., J.H. Gonzalez, M. Liva, T.H. Ngo. Effect of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro. Nutrition and Cancer 55:28-34,2006

Improve the Function of HDL Cholesterol
Roberts, C.K., C. Ng, S. Hama, R.J. Barnard. Effect of a diet and exercise intervention on inflammatory/anti-inflammatory properties of HDL in men with cardiovascular risk factors. J. Appl. Physiol. 101:1727-1732,2006

Alleviate the Metabolic Syndrome
Sullivan S, Klein S. Effect of a short-term Pritikin diet therapy on the metabolic syndrome. J Cardio Metab Syndrome. 1:308-312, 2006.

Scientists Affiliated With the Nathan Pritikin Research Foundation Also:

Investigated the Potential Health Benefits of Tea Consumption
Henning, S.M., W. Aronson, Y. Niu, F. Conde, N.H. Lee, N.P. Seeram, R-P. Lee, J. Lu, D.M. Harris, A. Moro, J. Hong, P-S. Leung, R.J. Barnard, H.G. Ziaee, G. Csathy, V.L.W. Go, H. Wang, D. Heber. Bioavailability and bioactivity of tea polyphenols in humans and mice after green and black tea consumption. J Nutr. 136:1839-1843,2006

Investigated the Potential Health Benefits of Pomegranate Juice Consumption
Pantuk, A.J., J.T. Leppert, W. Aronson, J. Hong, R.J. Barnard, N. Seeram, H. Wang, R. Elashoff, D. Heber, L. Ignarro, A. Belldegrun. Phase II study of pomegranate juice for men with rising PSA following surgery or radiation for prostate cancer. Clin. Cancer Res. 12:4018-4026,2006

Studied the Effects of Omega-6/Omega-3 Ratios On Prostate Cancer Cells
Kobayaski, N., R.J. Barnard, S.M. Henning, D. Elashoff, S.T. Reedy, P. Leung, J. Hong-Gonzalez, S.J. Freedland, J. Said, D. Gui, N.P. Seeram, L.M. Popoviciu, D. Bagga, D. Heber, J.A. Glaspy, W.J. Aronson. Effect of Altering Dietary Omega-6: Omega-3 Fatty Acid Ratios on Prostate Cancer Membrane Composition, Cyclooxygenase-2 and Prostaglandin E-2. Clin Cancer Res. 12:4662-4670,2006

2005 Research Studies

High-Fat, Refined Carbohydrate Diet Leads To Inflammation, Heart Disease
Roberts, C.K., R.J. Barnard, R.K. Sindhu, M. Jurczak, A. Ehdaie, N.D. Vasiri. A high-fat, refined carbohydrate diet induces endothelial dysfunction, oxidant/antioxidant imbalance and depresses NO synthase protein expression. J Appl Physiol 98:203-210, 2005.

The Pritikin Program Was Found To Reduce Cancer Cell Growth
Barnard, R.J. and W.J. Aronson. Preclinical models relevant to diet, exercise, and cancer. In: Recent Results in Cancer Research (Controversies in Tumor Prevention and Genetics III). H-J. Senn and R. Morant, eds. Springer 2005, 166:47-62.

The Pritikin Program Was Found To Control Diabetes and Hypertension And, For Many, Eliminate the Need For Drugs
Roberts, C.K. and Barnard, R.J. Effect of diet and exercise on chronic disease. J Appl Physiol 98:3-30, 2005.

Lifestyle Changes Halt Progression of Early-Stage Prostate Cancer
Ornish D, Carroll PR, Fair WR, Pettengill EB, Marlin R, Raisin CJ, Dunn-Emke S, Crutchfield L, Barnard RJ, McCormac P, McNight DJ, Fein JD, Dnstrian AM, Weinstein J, Ngo T, Weidner G. Intensive lifestyle changes may affect the progression of prostate cancer. J Urol 174:1065-1070, 2005.

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